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Read the case study.
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Submit your answers to the following questions:
Describe the steps of excitaon-contracon coupling. Start with acetylcholine being released from the motor neuron and end with myosin binding to acn. You may draw a diagram in addion to your explanaon. Be sure to include the following terms: acetylcholine receptor, acon potenal, calcium, calcium-release channels, muscle cell, T tubules, troponin, voltage-gated calcium ion channel, and voltage-gated sodium ion channel.
Explain how depleting ATP would increase skeletal muscle cell protease and lipase activity and the potential for apoptosis.
If there was a dramatic increase in skeletal muscle cell damage and apoptosis, what would you expect to happen to levels of myoglobin and CK in the blood?
Rachel’s test results showed elevated plasma K+ levels. What specific changes in Rachel’s muscle cells would cause this?
González placed Rachel on intravenous (IV) normal saline solution for several days. Explain what you would expect to happen to plasma K+ and CK concentrations.
Interested in learning more about rhabdomyolysis? Check out this optional reading
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